4-Bromo-1,1-difluorobut-1-ene → 4,4-Difluorobut-3-enyl thioacetate

HRID 618189

反応式

HRID 618189 の反応式
[C:1]([O-:4])(=[S:3])[CH3:2].[K+].Br[CH2:7][CH2:8][CH:9]=[C:10]([F:12])[F:11]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:4][CH2:7][CH2:8][CH:9]=[C:10]([F:12])[F:11])(=[S:3])[CH3:2]

参加物

4

反応物 2

HCID 27822404-Bromo-1,1-difluorobut-1-eneHCID 23670855Potassium ethanethioate

生成物 1

HCID 538607444,4-Difluorobut-3-enyl thioacetate収率 38.9%

試薬・触媒・溶媒 1

HCID 74236Tetrabutylammonium Bromide触媒

実験手順

Potassium thioacetate (1.98 g), 4-bromo-1,1-difluorobut-1-ene (3.0 g) and tetra-n-butylammonium bromide (0.3 g, catalyst) were stirred at the ambient temperature under nitrogen for 5 hours and stored for 18 hours. The mixture was distilled using a Kugelrohr apparatus to give 4,4-difluorobut-3-enyl thioacetate as a colourless liquid (1.12 g); 1H NMR; δ 2.25(2H,m); 2.30(3H,s); 2.90(2H,t); 4.20(1H,m); (bp 115° C. at 120 mmHg).

後処理

  1. distillationThe mixture was distilled

出典と根拠

ORDレコード
ord-558c03d7f31842ddaf8c340c0ad0e533
出典データセット
uspto-grants-1999_09
特許番号
US05952359

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