N-methanesulfonyl-6-hydroxymethylindole → 5-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene

HRID 618247ノート

反応式

HRID 618247 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12]O)[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[CH3:8].CS(N1C2C(=CC=C(C[Br:28])C=2)C=C1)(=O)=O.CS(N1C2C(=CC=C(CO)C=2)C=C1)(=O)=O>>[Br:28][CH2:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]([CH3:8])=[C:2]([Cl:1])[CH:3]=1

参加物

4

反応物 3

HCID 18789614N-methanesulfonyl-6-hydroxymethylindoleHCID 18789641N-methanesulfonyl-6-bromomethylindoleHCID 18789738(3-Chloro-4-methyl-5-nitrophenyl)methanol

生成物 1

HCID 187896735-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene

実験手順

5-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene was prepared from (3-chloro-4-methyl-5-nitrophenyl)methanol in a manner similar to that described in Example 10 for the preparation of N-methanesulfonyl-6-bromomethylindole from N-methanesulfonyl-6-hyroxymethyl indole.

出典と根拠

ORDレコード
ord-43b921327faf4ed4a52e62a784e02be2
出典データセット
uspto-grants-1999_09
特許番号
US05952362

反応ノート

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