1-methanesulfonyl-3-methyl-6-nitro-1H-indole → 1-methanesulfonyl-3-methyl-6-amino-1H-indole
反応式
[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[C:7]([CH3:17])=[CH:6]1)(=[O:4])=[O:3]>C(O)C.[Pt]=O>[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[C:7]([CH3:17])=[CH:6]1)(=[O:4])=[O:3]参加物
4
実験手順
A mixture of 1-methanesulfonyl-3-methyl-6-nitro-1H-indole (1.17 g, 4.60 mmol) and platinum oxide (52 mg, 0.23 mmol) in 20 ml of absolute ethanol was stirred at room temperature under an atmosphere of hydrogen gas for 12 hr. The mixture was filtered through a fine Whatman glass fiber filter to remove the catalyst. A quantitative amount of 1-methanesulfonyl-3-methyl-6-amino-1H-indole was obtained after removing the ethanol at reduced pressure.
後処理
- filtrationThe mixture was filtered through a fine Whatman glass fiber
- filtrationfilter
- customto remove the catalyst
出典と根拠
- ORDレコード
- ord-92379c8546ed4fa1928c92a7f3c39071
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05952362
反応ノート
読み込み中…