Triethylamine → 3-(4-Trifluoromethylbenzamido)propan-1-ol

HRID 618406

反応式

HRID 618406 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>ClCCl>[F:13][C:14]([F:24])([F:25])[C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[O:20])=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 90863-Amino-1-propanolHCID 676074-(Trifluoromethyl)benzoyl chloride

生成物 1

HCID 220068303-(4-Trifluoromethylbenzamido)propan-1-ol収率 85%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A reaction vessel was charged with 7.51 g of 3-amino-1-propanol, 2.53 g of triethylamine and 50 ml of dichloromethane, and 5.21 g of 4-trifluoromethylbenzoyl chloride was slowly added dropwise under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was successively washed with diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated, which afforded 5.25 g of 3-(4-trifluoromethylbenzamido)propan-1-ol (85% yield).

後処理

  1. additionwas slowly added dropwise under ice cooling
  2. washthe reaction mixture was successively washed with diluted hydrochloric acid and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-76ee336123e34623bfc57fb3c8e6cf87
出典データセット
uspto-grants-1999_09
特許番号
US05952386

関連ノート

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