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Methyl butyrate → HCID 178456762、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl butyrate | HCID 12180 | — |
| 反応物 | pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate | HCID 21847799 | — |
| 反応物 | methyl (2S)-2-amino-4-(1H-1,2,3,4-tetrazol-5-yl)butanoate | HCID 178501500 | — |
| 生成物 | HCID 178456762 | HCID 178456762 | — |
反応手順
Using analogous procedures to those described in Example 1 pentafluorophenyl p-{N-[1-(2,7-dimethyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzoate was reacted with methyl (2S)-2-amino-4-(tetrazol-5-yl)butyrate and the resultant methyl butyrate was hydrolysed to give 2- {p-{N-[1-(2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)ethyl]-N-(prop-2-ynyl)amino}benzamido}-4-(tetrazol-5-yl)butyric acid in 25% yields m.p. 207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05955463 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-aa05807e024d4971adce787a3e9ef0e8 |
| 出典メモ | uspto-grants-1999_09 |