Ammonia → Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

HRID 618747ノート

反応式

HRID 618747 の反応式
[C:1]([O:5][C:6](=[O:14])[C:7]([C:12]#[N:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2].N>C(O)C.[Ni]>[C:1]([O:5][C:6](=[O:14])[C:7]([CH2:12][NH2:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:2])([CH3:4])[CH3:3]

参加物

5

反応物 2

HCID 222AmmoniaHCID 54237674Tert-butyl 2-cyano-2-ethylbutanoate

生成物 1

HCID 54399069Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

29.21 g of 2-cyano-2-ethylbutyric acid tert-butyl ester, dissolved in 300 ml of ethanol, which contains 4% ammonia, are hydrogenated after normal pressure at 40° in the presence of 6 g of Raney nickel. After separating off from the catalyst, the batch is concentrated by evaporation in vacuo and the liquid that remains is distilled in vacuo to yield 2-aminomethyl-2-ethylbutyric acid tert-butyl ester, boiling point 65° at 0.6 mbar.

後処理

  1. customat 40°
  2. customAfter separating off from the catalyst
  3. concentrationthe batch is concentrated by evaporation in vacuo
  4. distillationthe liquid that remains is distilled in vacuo

出典と根拠

ORDレコード
ord-48d2ab7a855b4de19421f2e34386267e
出典データセット
uspto-grants-1999_09
特許番号
US05955487

反応ノート

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