1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene → 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochlorid

HRID 6188

反応式

HRID 6188 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]([C:35](=[O:38])[CH2:36][CH3:37])[CH2:24][CH2:25][CH2:26][CH2:27][S:28][C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[C:13](=[O:16])[CH2:14][CH3:15])=[CH:3][CH:2]=1.[ClH:39].CO>CO>[ClH:39].[ClH:39].[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]([C:35](=[O:38])[CH2:36][CH3:37])[CH2:24][CH2:25][CH2:26][CH2:27][S:28][C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[C:13](=[O:16])[CH2:14][CH3:15])=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 190791281,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzeneHCID 21893726Hydrochloride methanol

生成物 1

HCID 190792291,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochlorid収率 74.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 840 mg (1.53 mmol) of 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene in 20 ml of methanol, 80 ml of 10% hydrochloric acid/methanol was added, and the mixture was stirred for 30 minutes. The solvent was distilled off and the residue was recrystallized from ethanol/ether to give 707 mg of the desired product (74.1% yield, pale yellow crystals).

後処理

  1. distillationThe solvent was distilled off
  2. customthe residue was recrystallized from ethanol/ether

出典と根拠

ORDレコード
ord-84de096b7dbe4838b438dd20613401fa
出典データセット
uspto-grants-1993_09
特許番号
US05246948

関連ノート

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