Potassium Hydroxide → 2-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

HRID 61894ノート

反応式

HRID 61894 の反応式
C([O:3][C:4](=[O:16])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[N:9]=1)([CH3:7])[CH3:6])C.[OH-].[K+]>CO>[CH3:15][O:14][C:10]1[N:9]=[C:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])[CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 668349252-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester

生成物 1

HCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid収率 76.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester (5.33 g) was dissolved in methanol (200 ml), added with 5 N aqueous solution of potassium hydroxide (25 ml), and then stirred under reflux. The reaction mixture was concentrated and neutralized with 2 N hydrochloric acid. The precipitated matters were collected by filtration and dried to obtain the title compound (3.55 g).

後処理

  1. temperatureunder reflux
  2. concentrationThe reaction mixture was concentrated
  3. filtrationThe precipitated matters were collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-68ac0fb7778f4719bde87654e031adc3
出典データセット
uspto-grants-2016_09
特許番号
US09440922B2

反応ノート

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