化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → Bicyclo[2.2.1]heptane-1,2-diol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Oxygen | HCID 977 | — |
| 反応物 | Bicyclo(2.2.1)heptane | HCID 9233 | — |
| 反応物 | N-Hydroxyphthalimide | HCID 10665 | — |
| 生成物 | Bicyclo[2.2.1]heptan-1-ol | HCID 524266 | 44% |
| 生成物 | Bicyclo[2.2.1]heptane-1,2-diol | HCID 19960695 | 55% |
反応手順
A mixture of 0.96 gram (10 millimoles) of norbornane, 0.13 gram (0.8 millimole) of N-hydroxyphthalimide, 0.015 gram (0.06 millimole) of Co(AA)2 and 10 milliliters of acetic acid was stirred in an oxygen atmosphere at a temperature of 75° C. for 15 hours to give 1-hydroxynorbornane (selectivity for norbornane 44%, yield 44%) and 1,2-dihydroxynorbornane (selectivity for norbornane 55%, yield 55%) with a transformation rate of norbornane of 99% and the selectivity for the alcohols of 99%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05958821 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-ebbee50fe7934b388d26ba657215c847 |
| 出典メモ | uspto-grants-1999_09 |