関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(2-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide | HCID 21845595 | — |
反応手順
A solution of 5.8 g of 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone in 44 ml of methanol was treated at room temperature with 2.2 g of thiourea and boiled for 1 hour. 2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05958910 |
|---|
| 出典データセット | uspto-grants-1999_09 |
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| ORD ID | ord-f4535cf8a7314c42ba0ce4655d0e8876 |
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| 出典メモ | uspto-grants-1999_09 |
|---|
