Thiourea → 4-(3-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide

HRID 619078ノート

反応式

HRID 619078 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([F:15])[CH:6]=1)=O.[NH2:16][C:17]([NH2:19])=[S:18]>CO>[BrH:1].[F:15][C:7]1[CH:6]=[C:5]([C:3]2[N:16]=[C:17]([NH2:19])[S:18][CH:2]=2)[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=1

参加物

4

反応物 2

HCID 2723790ThioureaHCID 27789302-Bromo-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethan-1-one

生成物 1

HCID 218455794-(3-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

A solution of 7.2 g of 2-bromo-1-(3-fluoro-5-trifluoromethyl-phenyl)-ethanone in 60 ml of methanol was treated at room temperature with 2.7 g of thiourea and boiled for 1 hour. 5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.

後処理

  1. custom5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
  2. additionafter the addition of 15 ml of diethyl ether

出典と根拠

ORDレコード
ord-2a2f8ee9627a43868c8988f663f1fa99
出典データセット
uspto-grants-1999_09
特許番号
US05958910

反応ノート

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