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2-Ethylhexyl glycidyl ether → 1-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(2-ethylhexyloxy)-propan-2ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Ethylhexyl glycidyl ether | HCID 17162 | — |
| 反応物 | 4-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide | HCID 21845223 | — |
| 触媒 | Phosphonium, ethyltriphenyl-, bromide (1:1) | HCID 73727 | — |
| 生成物 | 1-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(2-ethylhexyloxy)-propan-2ol | HCID 19080636 | 70% |
反応手順
4-(1,1-dioxo-thiomorpholin-4-yl)phenol (4.1 g, 18 mmol), 2-ethylhexyl glycidyl ether (4.4 g, 23,6 mmol) and ethyltriphenylphosphonium bromide (0.37 g) are heated under nitrogen for 5 h at 145° C. and the crude product is chromatographed over silica gel (hexane/ethylacetate 1:1) to afford a colourless liquid 5.2 g (70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05958663 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-39b458af6e5e42c3b9cba30a11e20b0c |
| 出典メモ | uspto-grants-1999_09 |