2-((1,1-Dimethylethoxy)methyl)oxirane → 1-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(t-butyloxy)propan-2-ol

HRID 619095

反応式

HRID 619095 の反応式
[O:1]=[S:2]1(=[O:15])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:16]([O:20][CH2:21][CH:22]1[O:24][CH2:23]1)([CH3:19])([CH3:18])[CH3:17]>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C>[O:15]=[S:2]1(=[O:1])[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:23][CH:22]([OH:24])[CH2:21][O:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:12][CH:13]=2)[CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 243142-((1,1-Dimethylethoxy)methyl)oxiraneHCID 218452234-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide

生成物 1

HCID 218452211-[4-(1,1-Dioxo-thiomorpholin-4-yl)-phenoxy]-3-(t-butyloxy)propan-2-ol収率 78.3%

試薬・触媒・溶媒 1

HCID 73727Phosphonium, ethyltriphenyl-, bromide (1:1)触媒

実験手順

4-(1,1-dioxo-thiomorpholin-4-yl)phenol (2.3 g, 10 mmol), t-butylglycidyl ether (1.56 g, 12 mmol) and ethyltriphenylphosphonium bromide (0.1 g) are reacted and purified as described for compound 102 to afford a light yellow liquid 2.8 g (78%).

後処理

  1. custompurified

出典と根拠

ORDレコード
ord-1f9c5ef8ab5448cfb6e3d1a81695b64d
出典データセット
uspto-grants-1999_09
特許番号
US05958663

関連ノート

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