Diethyl Ether → HCID 21846123、化合物

HRID 619124ノート

反応式

HRID 619124 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:29][C:12]2=[N:13][C:14]([CH3:28])=[C:15]([C:25](=[O:27])[CH3:26])[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[N:11]2[CH:10]=1.C(OCC)C>Cl>[ClH:1].[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[S:29][C:12]2=[N:13][C:14]([CH3:28])=[C:15]([C:25](=[O:27])[CH3:26])[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[N:11]2[CH:10]=1

参加物

4

反応物 2

HCID 3283Diethyl EtherHCID 11123147HCID 11123147、化合物

生成物 1

HCID 21846123HCID 21846123、化合物収率 145.9%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

1.95 g (4.38 mmol) of (RS)-1-[2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]ethanone were dissolved in 20 ml of methanolic hydrochloric acid solution (2.6N) while stirring and treated with 100 ml of diethyl ether. After 1 h the crystals were filtered off. There were obtained 1.54 g (73%) of (RS)-1-[2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]ethanone hydrochloride as a beige solid with m.p. 165° C.

後処理

  1. filtrationAfter 1 h the crystals were filtered off

出典と根拠

ORDレコード
ord-55b12e5db1e14e49a420d8cf96d79447
出典データセット
uspto-grants-1999_09
特許番号
US05958931

反応ノート

読み込み中…