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Salicylaldehyde → 2-(2-Morpholinoethoxy)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Salicylaldehyde | HCID 6998 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(2-Morpholinoethoxy)benzaldehyde | HCID 976593 | — |
反応手順
To a solution of salicylaldehyde (2 ml) in acetonitrile (20 ml) was added K2CO3 (5.71 g), followed by N-(2-chloroethyl)morpholine hydrochloride (3.5 g) and then the mixture was stirred at room temperature for 2 hours, then at reflux overnight. The reaction mixture was cooled to room temperature, filtered, and the filtrate was concentrated in vacuo to afford 2-[2-(4-morpholinyl)ethoxy]benzaldehyde, as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05958929 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-5ea47cfc774c4e04a4b58b4e7e74100b |
| 出典メモ | uspto-grants-1999_09 |