3-(2-Morpholino-2-oxoethoxy)benzaldehyde → HCID 178437847、化合物

HRID 619189ノート

反応式

HRID 619189 の反応式
[CH:1]1([N:6]2[C:10]([NH2:11])=[C:9]([C:12]([NH2:14])=[O:13])[C:8]([CH2:15][CH3:16])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:17]1([C:23]([CH2:25][O:26][C:27]2[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=2)[CH:30]=O)=[O:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH:1]1([N:6]2[C:10]3=[N:11][C:30]([C:29]4[CH:32]=[CH:33][CH:34]=[C:27]([O:26][CH2:25][C:23]([N:17]5[CH2:22][CH2:21][O:20][CH2:19][CH2:18]5)=[O:24])[CH:28]=4)=[N:14][C:12](=[O:13])[C:9]3=[C:8]([CH2:15][CH3:16])[NH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

3

反応物 2

HCID 164955713-(2-Morpholino-2-oxoethoxy)benzaldehydeHCID 224493525-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide

生成物 1

HCID 178437847HCID 178437847、化合物

反応条件

温度
160 °C

実験手順

A mixture of 1-cyclopentyl-3-ethyl-5-amino-1H-pyrazole-4-carboxamide (1.87 g), 3-[4-morpholinylcarbonylmethoxy]benzaldehyde (2.1 g, 8.43 mmol) and xylenes (20 ml) was heated at 160° C. for about 2 days. The solvent was removed, then methanol was added to the residue and the product was collected by filtration. Additional product was obtained from the filtrates and the product fractions were pooled and recrystallized from CH3CN/CHCl3 to afford 1-cyclopentyl-3-ethyl-6-[3-(4-morpholinylcarbonylmethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-4-one, m.p. 212-213° C.

後処理

  1. customThe solvent was removed
  2. additionmethanol was added to the residue
  3. filtrationthe product was collected by filtration
  4. customAdditional product was obtained from the filtrates
  5. customrecrystallized from CH3CN/CHCl3

出典と根拠

ORDレコード
ord-294ca64a56334c18bea5079ae8742a13
出典データセット
uspto-grants-1999_09
特許番号
US05958929

反応ノート

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