Sulfuryl chloride → HCID 178472913、化合物
反応式
[OH:1]/[N:2]=[C:3](/[C:9](=[O:12])[CH2:10][CH3:11])\[C:4]([O:6][CH2:7][CH3:8])=[O:5].S(Cl)([Cl:16])(=O)=O>C(O)(=O)C>[Cl:16][CH:10]([CH3:11])[C:9](=[O:12])/[C:3](=[N:2]/[OH:1])/[C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
実験手順
A solution of ethyl 2-(Z)-hydroxyimino-3-oxopentanoate (10 g) in 10 ml of acetic acid was cooled to 0° C. and treated dropwise with sulfuryl chloride (5.3 ml). The mixture was stirred for 3 hours at room temperature and quenched by ice-water. The mixture was extracted with ethyl acetate, and the extracts were washed with brine and dried with magnesium sulfate. The solvent was removed under reduced pressure to afford ethyl 4-chloro-2-(Z)-hydroxyimino-3-oxopentanoate (11.97 g).
後処理
- customquenched by ice-water
- extractionThe mixture was extracted with ethyl acetate
- washthe extracts were washed with brine
- dry with materialdried with magnesium sulfate
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-6702067a190c4915a4f2312f5b8bb765
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05958914
反応ノート
読み込み中…