1-Chloromethylnaphthalene → 1-Naphthaleneacetonitrile

HRID 619349

反応式

HRID 619349 の反応式
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[C-:13]#[N:14].[K+]>CN(C=O)C.[I-].[K+]>[C:3]1([CH2:2][C:13]#[N:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 68451-ChloromethylnaphthaleneHCID 9032Potassium Cyanide

生成物 1

HCID 85961-Naphthaleneacetonitrile収率 98%

試薬・触媒・溶媒 2

HCID 4875Potassium Iodide触媒HCID 6228Dimethylformamide溶媒

実験手順

1-Chloromethyinaphthalene (5.00 ml, 33 mmol) was dissolved in N,N'-dimethylformamide (50 ml) and potassium cyanide (4.31 g, 66 mmol) and potassium iodide (0.1 g) were added and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was partitioned between water (150 ml) and diethyl ether (2×100 ml). The combined organic phases were washed with water (100 ml), dried (MgSO4), filtered and concentrated in vacuo affording 5.41 g (98%) of 1-naphtylacetonitrile as an oil.

後処理

  1. customThe reaction mixture was partitioned between water (150 ml) and diethyl ether (2×100 ml)
  2. washThe combined organic phases were washed with water (100 ml)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-de3f8fa39a1048f5b83f53a4b54780a8
出典データセット
uspto-grants-1999_09
特許番号
US05958957

関連ノート

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