N-(tert-Butoxycarbonyl)-1,5-diaminopentane → 4,5-Dihydro-4[5-(tert-butoxycarbonylamino)pentan-1-yl]-3H-1,4,8b-triazaacenaphthylen-5-one

HRID 619441

反応式

HRID 619441 の反応式
[I-].C[N+:3]([CH2:6][C:7]1[N:11]2[C:12]([C:16]([O:18]CC)=O)=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)([CH3:5])C.[C:21]([O:25][C:26]([NH:28][CH2:29][CH2:30][CH2:31][CH2:32]CN)=[O:27])([CH3:24])([CH3:23])[CH3:22].C(N(CC)CC)C>>[C:21]([O:25][C:26]([NH:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:5][N:3]1[C:16](=[O:18])[C:12]2[N:11]3[C:7](=[CH:8][N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=2)[CH2:6]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]

参加物

4

反応物 3

HCID 4352N-(tert-Butoxycarbonyl)-1,5-diaminopentaneHCID 8471TriethylamineHCID 211901283-[(Trimethylammonio)methyl]-5-ethoxycarbonylimidazo[1,2-a]pyridine iodide

生成物 1

HCID 211901734,5-Dihydro-4[5-(tert-butoxycarbonylamino)pentan-1-yl]-3H-1,4,8b-triazaacenaphthylen-5-one収率 54.8%

実験手順

A solution of 7.78 g (20 mmol) of 3-[(trimethylammonio)methyl]-5-ethoxycarbonylimidazo [1,2-a]pyridine iodide, 6.07 g (30 mmol) of 5-tert-butoxycarbonylamino-1-pentylamine and 5.58 ml (40 mmol) of triethylamine was heated for 64 hours under reflux. The solvent was distilled off. To the residue was added methylene chloride, washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by column chromatography (eluent: ethyl acetate/ethanol=10:1) to afford 3.93 g of the desired compound (54.9%, a pale yellow solid).

後処理

  1. temperatureunder reflux
  2. distillationThe solvent was distilled off
  3. additionTo the residue was added methylene chloride
  4. washwashed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off
  7. customthe residue was purified by column chromatography (eluent: ethyl acetate/ethanol=10:1)

出典と根拠

ORDレコード
ord-fe3959d2b56d42c4b63412223c5abdc6
出典データセット
uspto-grants-1999_09
特許番号
US05958942

関連ノート

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