Hydrochloric Acid → 4,5-Dihydro-4-(4-pentafluoropropion amidobutan-1-yl)-3h-1,4,8b-triazaacenaphthylene.dihydrochloride
反応式
[F:1][C:2]([F:26])([C:22]([F:25])([F:24])[F:23])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)=[O:4].[ClH:27]>C(O)C>[ClH:27].[ClH:27].[F:26][C:2]([F:1])([C:22]([F:23])([F:24])[F:25])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:20][C:19]2[N:21]3[C:12](=[CH:13][N:14]=[C:15]3[CH:16]=[CH:17][CH:18]=2)[CH2:11]1)=[O:4]参加物
4
実験手順
To a solution of 2230 mg (5.93 mmol) of 4,5-dihydro-4-(4-pentafluoropropionamidobutan-1-yl)-3H-1,4,8b-triazaacenaphthylene in 35 ml of ethanol was added 1.22 ml (14.31 mmol) of 12N hydrochloric acid. The mixture was stirred for one hour at room temperature. The resulting precipitates was collected by filtration, washed with a small volume of ethanol and ether, and dried to afford 2120 mg of the desired compound (76.9%, white crystals).