関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Fluoro-3-nitroaniline | HCID 67768 | — |
| 反応物 | 5-Isoquinolinethiol | HCID 11051963 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(5-Isoquinolylsulfanyl)-3-nitroaniline | HCID 21846909 | 96.5% |
反応手順
5-Isoquinolinethiol 1.00 g (6.2 mmol) was dissolved in DMF 14 ml, potassium carbonate 1.01 g (7.3 mmol) and 4-fluoro-3-nitroaniline 0.96 g (6.1 mmol) were added and the mixture was heated with stirring for 2 hours at 100° C. The reaction solution was concentrated under reduced pressure, the resulting residue was washed with water to obtain 4-(5-isoquinolylsulfanyl)-3-nitroaniline 1.75 g (96.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05959107 |
|---|
| 出典データセット | uspto-grants-1999_09 |
|---|
| ORD ID | ord-318b0d5941c04fb2a4d3d90fcc4e93c2 |
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| 出典メモ | uspto-grants-1999_09 |
|---|
