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Potassium Carbonate → 4-(5-Isoquinolylsulfanyl)-3-nitrobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzonitrile, 4-chloro-3-nitro- | HCID 13655 | — |
| 反応物 | 5-Isoquinolinethiol | HCID 11051963 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(5-Isoquinolylsulfanyl)-3-nitrobenzonitrile | HCID 21846933 | 100% |
反応手順
According to the method in Example 10, 5-isoquinolinethiol 1.00 g (6.2 mmol) was dissolved in DMF 14 ml, potassium carbonate 1.60 g (11.6 mmol) and 4-chloro-3-nitrobenzonitrile 1.00 g (5.5 mmol) were added and stirred at room temperature for 15 minutes, and 4-(5-isoquinolylsulfanyl)-3-nitrobenzonitrile 1.69 g (quantitative) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05959107 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-9f3f182812b1465cb289eefd22c0a122 |
| 出典メモ | uspto-grants-1999_09 |