Potassium Carbonate → 4-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline

HRID 619729ノート

反応式

HRID 619729 の反応式
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[C:25](Cl)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1>CN(C=O)C>[Cl:18][C:19]1[C:25]([S:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 811494,5-Dichloro-2-nitroanilineHCID 110519635-Isoquinolinethiol

生成物 1

HCID 218469034-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline収率 98.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 15 ml, potassium carbonate 830 mg (6.0 mmol) and 4,5-dichloro-2-nitroaniline 620 mg (3.0 mmol) were added, and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and the resulting precipitates were collected and washed with water to give 4-chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline 980 mg (98.4%).

後処理

  1. customthe resulting precipitates
  2. customwere collected
  3. washwashed with water

出典と根拠

ORDレコード
ord-2aa0d5973a264f50a9117edd28e1e3fd
出典データセット
uspto-grants-1999_09
特許番号
US05959107

反応ノート

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