関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Isoquinolinethiol | HCID 11051963 | — |
| 反応物 | 6-chloro-1-ethyl-2-methyl-5-nitro-1H-benzo[d]imidazole | HCID 21846946 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-ethyl-6-(5-isoquinolylsulfanyl)-2-methyl-5-nitro-1H-benzo[d]imidazole | HCID 21846962 | 36.3% |
反応手順
5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 20 ml, 6-chloro-1-ethyl-2-methyl-5-nitro-1H-benzo[d]imidazole 910 mg (3.1 mmol) and potassium carbonate 1.29 g (9.3 mmol) were added, and the mixture was stirred for 6 hours at 130° C. The reaction mixture was concentrated under reduced pressure, the residue was crystallized with ethyl acetate, and 1-ethyl-6-(5-isoquinolylsulfanyl)-2-methyl-5-nitro-1H-benzo[d]imidazole 410 mg (35.8%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05959107 |
|---|
| 出典データセット | uspto-grants-1999_09 |
|---|
| ORD ID | ord-419f836f31444b5ea88aa33c5bb92832 |
|---|
| 出典メモ | uspto-grants-1999_09 |
|---|
