1-benzyl-2-(chloromethyl)-1H-imidazole → 7-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]-(1-benzyl-1H-imidazol-2-ylmethyl)amide

HRID 619815

反応式

HRID 619815 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2].[CH2:32]([N:39]1[CH:43]=[CH:42][N:41]=[C:40]1[CH2:44]Cl)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:44][C:40]2[N:39]([CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH:43]=[CH:42][N:41]=2)[S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2]

参加物

3

反応物 2

HCID 7367921-benzyl-2-(chloromethyl)-1H-imidazoleHCID 105508547-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

生成物 1

HCID 867545647-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]-(1-benzyl-1H-imidazol-2-ylmethyl)amide

実験手順

The title compound is prepared as described in EXAMPLE 90, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 43, part A, and 1-benzyl-1H-imidazol-2-ylmethyl chloride. The crude product is purified by column chromatography eluting with 2% MeOH/CH2Cl2 to afford the title compound as a white foam.

後処理

  1. customThe title compound is prepared
  2. customprepared
  3. customThe crude product is purified by column chromatography
  4. washeluting with 2% MeOH/CH2Cl2

出典と根拠

ORDレコード
ord-c67c0c024493443e95322b0e1bc3b252
出典データセット
uspto-grants-1999_09
特許番号
US05958918

関連ノート

読み込み中…