Hydrochloric Acid → 4-Methyl-1-naphthol

HRID 619872

反応式

HRID 619872 の反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12]C)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1.Cl>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 43814674-Methoxy-1-methylnaphthaleneHCID 10176127Pyridinium chloride

生成物 1

HCID 824834-Methyl-1-naphthol

反応条件

温度
200 °C

実験手順

4-Methyl-1-methoxynaphthalene (4) (145 g) was mixed with pyridine hydrochloride (250 g) and the mixture was heated at 200° C. for 3 hours. The mixture was cooled, treated with dilute hydrochloric acid, and extracted with ether. The ether extract was dried (MgSO4), filtered and the solvent removed, leaving a black oil which was extracted with petroleum b.p. 60°-80° C. (4×100 cm3). 4-Methyl-1-naphthol (5) was obtained as near colourless oily crystals which darken on storage.

後処理

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. dry with materialwas dried (MgSO4)
  5. filtrationfiltered
  6. customthe solvent removed
  7. customleaving a black oil which
  8. extractionwas extracted with petroleum b.p. 60°-80° C. (4×100 cm3)

出典と根拠

ORDレコード
ord-f30e9ede785445388d3e53904cba5691
出典データセット
uspto-grants-1989_04
特許番号
US04818096

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