Hydrochloric Acid → 4-Methyl-1-naphthol
反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12]C)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1.Cl>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 200 °C
実験手順
4-Methyl-1-methoxynaphthalene (4) (145 g) was mixed with pyridine hydrochloride (250 g) and the mixture was heated at 200° C. for 3 hours. The mixture was cooled, treated with dilute hydrochloric acid, and extracted with ether. The ether extract was dried (MgSO4), filtered and the solvent removed, leaving a black oil which was extracted with petroleum b.p. 60°-80° C. (4×100 cm3). 4-Methyl-1-naphthol (5) was obtained as near colourless oily crystals which darken on storage.
後処理
- temperatureThe mixture was cooled
- extractionextracted with ether
- extractionThe ether extract
- dry with materialwas dried (MgSO4)
- filtrationfiltered
- customthe solvent removed
- customleaving a black oil which
- extractionwas extracted with petroleum b.p. 60°-80° C. (4×100 cm3)
出典と根拠
- ORDレコード
- ord-f30e9ede785445388d3e53904cba5691
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04818096
反応ノート
読み込み中…