Ammonia → 1-Isopropyl-2-chloromethylbenzimidazole

HRID 620028ノート

反応式

HRID 620028 の反応式
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11])([CH3:3])[CH3:2].[Cl:12][CH2:13][C:14](O)=O.N>Cl>[CH:1]([N:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:11]=[C:14]1[CH2:13][Cl:12])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 222AmmoniaHCID 300Chloroacetic AcidHCID 105587871-N-(propan-2-yl)benzene-1,2-diamine

生成物 1

HCID 212484181-Isopropyl-2-chloromethylbenzimidazole収率 64.5%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

N-isopropyl-o-phenylenediamine (2.8 g, 18.6 mmol), which is a known compound, was reacted with monochloroacetic acid (2.64 g, 28 mmol) in hydrochloric acid. The reaction mixture was made to weak by alkaline alkali with aqueous ammonia and the obtained oily material was refined in a usual manner to give the title intermediate (2.5 g, 12 mmol).

出典と根拠

ORDレコード
ord-9a9dcfe126da47e186ba1a05709c8a76
出典データセット
uspto-grants-1989_04
特許番号
US04818761

反応ノート

読み込み中…