Ammonia → HCID 21248422、化合物

反応式

[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[NH:4][CH2:5][CH3:6].Cl.[Cl:13][CH2:14][C:15](O)=O.N>>[CH2:5]([N:4]1[C:3]2[CH:7]=[CH:8][C:9]([CH3:11])=[CH:10][C:2]=2[N:1]=[C:15]1[CH2:14][Cl:13])[CH3:6]

参加物

反応物 4

HCID 222Ammonia

HCID 300Chloroacetic Acid

HCID 313Hydrochloric Acid

HCID 14243606N1-ethyl-4-methylbenzene-1,2-diamine

生成物 1

HCID 21248422HCID 21248422、化合物収率 27.9%

実験手順

2-amino-4-methyl-N-ethylaniline (2.15 g, 14 mmol), which is a known compound, hydrochloric acid (4N, 15 ml) and monochloroacetic acid (2 g, 21 mmol) were refluxed for 2.5 hours. After cooling, the reactant was neutralized with ammonia. The occurred oily substance was extracted with ethyl acetate and the product was treated as in a usual process to obtain the title intermediate (1.0 g, 3.9 mmol).