4-Aminopyridine → HCID 14456465、化合物

HRID 620035ノート

反応式

HRID 620035 の反応式
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[CH2:17]Cl)[CH:5]=[CH:6][CH:7]=1.[NH2:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[CH2:17][NH:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 17274-AminopyridineHCID 212484162-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

生成物 1

HCID 14456465HCID 14456465、化合物収率 20.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A ethanol (8 ml) solution of 1-(3-fluorophenyl)-2-chloromethylbenzimidazole (1.0 g, 4 mmol) prepared in the preceding step (b) and 4-aminopyridine (1.3 g, 7.4 mmol) was refluxed for 1.5 hours. The reaction mixture was concentrated in vacuo and crystallized from acetone and recrystallized from ethanol-acetone, then the objective compound (0.3 g, 0.82 mmol) was obtained.

後処理

  1. temperaturewas refluxed for 1.5 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customcrystallized from acetone
  4. customrecrystallized from ethanol-acetone

出典と根拠

ORDレコード
ord-c19ce065174e41bfa6121f39389b6ce6
出典データセット
uspto-grants-1989_04
特許番号
US04818761

反応ノート

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