Ethyl 2-oxocyclohexanecarboxylate → HCID 14053650、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH2:12].CC[O:15][C:16]([CH:18]1[C:23](=O)[CH2:22][CH2:21][CH2:20][CH2:19]1)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]1[C:16](=[O:15])[C:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[NH:12]1参加物
3
実験手順
A solution of 2-fluoro-5-nitrophenylhydrazine (53.95 g) in ethyl 2-cyclohexanonecarboxylate (53.65 g) was heated under reflux for 4 hours. After cooling, the reaction mixture was poured into ice-water. The precipitated crystals were collected by filtration, washed with water and hexane and dried to obtain 2-(2-fluoro-5-nitrophenyl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-one. m.p., 220.0° C.
後処理
- temperatureunder reflux for 4 hours
- temperatureAfter cooling
- filtrationThe precipitated crystals were collected by filtration
- washwashed with water and hexane
- customdried
出典と根拠
- ORDレコード
- ord-626cb7e833b34fb59fc7615e6a460237
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04820333
反応ノート
読み込み中…