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1-Naphthaleneacetonitrile → 8-Piperidino-2-(1-naphthyl)-octanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthaleneacetonitrile | HCID 8596 | — |
| 反応物 | Sodium amide | HCID 24533 | — |
| 反応物 | 1-(6-Chlorohexyl)piperidine | HCID 13806003 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 8-Piperidino-2-(1-naphthyl)-octanenitrile | HCID 21245867 | — |
反応手順
3.9 g of sodium amide are added in small quantities to 16.7 g of 1-naphthyl-acetonitrile in solution in 200 ml of anhydrous ether. After 2 hours of heating to reflux, 20.5 g of 6-piperidino-1-chloro-hexane are added and heating is continued to reflux for another 5 hours. Then, using the conventional methods, 30 g of product are isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04820717 |
| 出典データセット | uspto-grants-1989_04 |
| ORD ID | ord-d01eca2758cf4f3cb0af6e293f6d41bb |
| 出典メモ | uspto-grants-1989_04 |