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HRID 620289作成日：2026年10月26日
Acetone → 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide hydrochloride monohydrate
https://huagongshe.com/reaction/620289
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(2-(methylsulfinyl)ethoxy)benzamide | HCID 9822947 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide hydrochloride monohydrate | HCID 21245862 | — |
反応手順
A mixture of 4-amino-5-chloro-2[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide (84.50 g, 22.5 mmoles), acetone (592 ml) and 2-propanol (169 ml) was stirred and warmed until complete solution (ca. 25° C.) and then 56.2 ml of 4N HCl (1 equivalent) was all at once. The temperature rose to 32° C. After one hour at ambient temperature the mixture was stored at 0° C. for 18 hours. The hydrochloride salt was collected by filtration, rinses with acetone and dried in vacuo over P2O5 for six hours. Yield: 89.6 g (96.6%); mp 117°-124° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04820715 |
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| 出典データセット | uspto-grants-1989_04 |
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| ORD ID | ord-0cdd82d3d03e4f99b4b7d037fb45ca38 |
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| 出典メモ | uspto-grants-1989_04 |
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