HCID 19423821、化合物 → HCID 70045402、化合物
反応式
O.[N:2]1([C:13](=[O:14])[C:12]2[N:11]([CH2:15][C:16]([O-:18])=[O:17])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3].[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH3:47])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][C:32]([O:39][CH2:40][CH3:41])=[C:33]([O:36][CH2:37][CH3:38])[CH:34]=2)[CH2:29][CH2:28][NH+:27]=1)[CH3:20]>CC(C)=O>[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH3:47])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][C:32]([O:39][CH2:40][CH3:41])=[C:33]([O:36][CH2:37][CH3:38])[CH:34]=2)[CH2:29][CH2:28][NH+:27]=1)[CH3:20].[N:2]1([C:13](=[O:14])[C:12]2[N:11]([CH2:15][C:16]([O-:18])=[O:17])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3]参加物
3
実験手順
Into a 250 ml four-necked flask equipped with a stirrer 25 g of 1-(3',4'-diethoxy-benzyl)6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate-monohydrate and 250 ml of anhydrous acetone are weighed in. The reaction mixture is stirred at room temperature for 5 hours. The crystalline product is transformed into a loose yellowish-white thick substance, which is filtered, washed twice with 20 ml of acetone each and dried. Thus 23.5 g of the desired compound are obtained, yield 96.5%. mp: 152°-154° C. The product is identical with the substance prepared according to Example 4.
後処理
- filtrationis filtered