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HRID 620569作成日：2026年10月26日
Triethylamine → 1,3-Dihydro-5-(2-fluorophenyl)-3-(RS)-(3-thiophene carbonylamino)-2H-1,4-benzodiazepin-2-one
https://huagongshe.com/reaction/620569
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Thenoyl chloride | HCID 2776377 | — |
| 反応物 | 1,3-dihydro-5-(2-fluorophenyl)-3-amino-2H-1,4-benzodiazepin-2-one | HCID 15637150 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1,3-Dihydro-5-(2-fluorophenyl)-3-(RS)-(3-thiophene carbonylamino)-2H-1,4-benzodiazepin-2-one | HCID 14208217 | — |
反応手順
3-(RS)-Amino-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (75 mg, 0.229 mmol), thiophene-3-carbonyl chloride (44.9 mg, 0.306 mmol) and triethylamine (42.5 μl, 0.306 mmol) were combined in CH2Cl2 (4 ml) and stirred 10 min. at 25° C. The reaction was concentrated and chromatographed on silica gel (2% MeOH in CH2Cl2) to give the title compound as a white solid from Et2O: (m.p. 238°-239°).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04820834 |
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| 出典データセット | uspto-grants-1989_04 |
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| ORD ID | ord-09f8e8945ee34e2bb443c6e150cfe589 |
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| 出典メモ | uspto-grants-1989_04 |
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