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Potassium Carbonate → N-Hydroxyhexyl-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 反応物 | 6-Bromo-1-hexanol | HCID 77970 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-Hydroxyhexyl-1,2,3,4-tetrahydroquinoline | HCID 19795093 | — |
反応手順
A stirred solution of 133.2 g (1 mole) of 1,2,3,4-tetrahydroquinoline, 181.1 g (1 mole) of 6-bromohexanol, and 138.2 g (1 mole) of potassium carbonate in toluene is heated at 80° C. for 3 hours. The solution is cooled to room temperature, and the solids are removed by filtration. The solvent is removed in vacuo, and the N-hydroxyhexyltetrahydroquinoline is purified by chromatography (silica gel, hexane:ethyl acetate).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05247042 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-002d9f5f7d094a87a267a18d90638473 |
| 出典メモ | uspto-grants-1993_09 |