Acetic Anhydride → N-Acetoxyhexyl-1,2,3,4-tetrahydroquinoline

HRID 6207ノート

反応式

HRID 6207 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:17]2[CH:12]([CH2:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1.[C:18](OC(=O)C)(=[O:20])[CH3:19].C(N(CC)CC)C>ClCCl>[C:18]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)(=[O:20])[CH3:19]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 67859558N-hydroxyhexyltetrahydroquinoline

生成物 1

HCID 53737711N-Acetoxyhexyl-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 233.4 g (1 mole) of N-hydroxyhexyltetrahydroquinoline and 153.1 g (1.5 moles) of acetic anhydride in dichloromethane are added 151.8 g (1.5 moles) of triethylamine and 8.5 g (1 mole %) of 4-N,N-dimethylaminopyridine, and the reaction is stirred at room temperature for 3 hours. The product solution is washed with cold 2N HCl followed by saturated sodium bicarbonate, and the organic layer is filtered through cotton and evaporated.

後処理

  1. washThe product solution is washed with cold 2N HCl
  2. filtrationthe organic layer is filtered through cotton
  3. customevaporated

出典と根拠

ORDレコード
ord-bf199b56f7eb4319ac3c695eb26223f8
出典データセット
uspto-grants-1993_09
特許番号
US05247042

反応ノート

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