Butyl bromide → 4-n-Butoxy-3-methoxyphenylacetonitrile

HRID 620758

反応式

HRID 620758 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[O:11][CH3:12].[CH2:13](Br)[CH2:14][CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.C(OCC)C>[CH2:13]([O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[O:11][CH3:12])[CH2:14][CH2:15][CH3:16]

参加物

6

反応物 3

HCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 782204-Hydroxy-3-methoxyphenylacetonitrile

生成物 1

HCID 212451184-n-Butoxy-3-methoxyphenylacetonitrile収率 104.7%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 15 grams 4-hydroxy-3-methoxyphenylacetonitrile (91.91 mmol), 26.40 ml (33.59 grams) n-butyl bromide (245 mmol) and 21.17 grams potassium carbonate (153.2 mmol) in 150 ml acetone was heated to reflux under nitrogen for 18 hours. After cooling to room temperature, the mixture was diluted with diethyl ether and the inorganic salts were removed by filtration and were washed with diethyl ether. The filtrate and wash solutions were evaporated in vacuo to provide 21.11 grams of Compound 10c as a straw-colored viscous oil (99.9% yield) which was dried in vacuo at 50° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen for 18 hours
  3. customthe inorganic salts were removed by filtration
  4. washwere washed with diethyl ether
  5. washThe filtrate and wash solutions
  6. customwere evaporated in vacuo

出典と根拠

ORDレコード
ord-1b030cb11fdb45739ddbe13af48d1e94
出典データセット
uspto-grants-1989_04
特許番号
US04822800

関連ノート

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