Hydrochloric Acid → 4-(2-Hydroxyiminopropionyl)pyridine
反応式
[N:1](OCCC(C)C)=[O:2].C[O-].[Na+].[C:12]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)(=[O:15])[CH2:13][CH3:14].Cl>CO>[OH:2][N:1]=[C:13]([CH3:14])[C:12]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[O:15]参加物
6
実験手順
To a solution of isoamyl nitrite (2.6 ml) and sodium methoxide (28% in methanol, 3.4 ml) in methanol (40 ml) was added dropwise a solution of 4-propionylpyridine (2.0 g) in methanol (10 ml) under ice-cooling. The reaction mixture was stirred at ambient temperature for 3 hours, and then neutralized with 1N hydrochloric acid. After evaporation to remove methanol, the organic layer was extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, evaporated and triturated with diisopropyl ether to give 4-(2-hydroxyiminopropionyl)pyridine (0.95 g).
後処理
- temperaturecooling
- customAfter evaporation
- customto remove methanol
- extractionthe organic layer was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
- customtriturated with diisopropyl ether
出典と根拠
- ORDレコード
- ord-bb0d01142a9a4ba7b76eacf480d5f933
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04822805
反応ノート
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