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Water → 2-p-Tolylbenzoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Aminophenol | HCID 5801 | — |
| 反応物 | 4-Methylbenzaldehyde | HCID 7725 | — |
| 反応物 | HCID 178418268 | HCID 178418268 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-p-Tolylbenzoxazole | HCID 70039 | — |
反応手順
A solution of 12 g (0.1 mole) of 4-tolualdehyde and 10.9 g (0.1 mole) of 2-aminophenol in toluene is heated at reflux with azeotropic removal of water. After 20 hours at reflux, the reaction is cooled to room temperature, 44.3 g (0.1 mole) of lead tetraacetate is added, and the mixture is stirred at room temperature overnight. The solids are removed by filtration, and the filtrate is swirled with basic alumina. Removal of the solvent in vacuo affords the solid product which is then purified by recrystallization from benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05247042 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-a8c9dc88ef314c6e9a5ee94f173add5d |
| 出典メモ | uspto-grants-1993_09 |