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Azobisisobutyronitrile → Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | Succinimide | HCID 11439 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Methyl 3-methoxy-2-o-tolylacrylate | HCID 435882 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoate | HCID 53395349 | — |
反応手順
20.6 g of the methyl α-(2-methylphenyl)-β-methoxyacrylate obtained by Method A, 17.65 g of N-bromosuccinimide, 0.2 g of azodiisobutyronitrile and 150 ml of CCl4 are slowly heated to 90° C. This temperature is maintained until all the succinimide is floating on the solvent. Filtration is followed by concentrating, the remaining oil is dissolved in about 5 ml of acetone, and n-hexane is added to bring about crystallization. This gives 27.5 g of colorless crystals of mp 86°-87° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04822908 |
| 出典データセット | uspto-grants-1989_04 |
| ORD ID | ord-9b8c870e7d334ddbab992dc982eb8816 |
| 出典メモ | uspto-grants-1989_04 |