P-Anisidine → 9-(4-Methoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

関与物質

役割	名称	HCID	仕込み量
反応物	P-Anisidine	HCID 7732	—
反応物	Potassium Bromide	HCID 253877	—
反応物	HCID 178484237	HCID 178484237	—
溶媒	Dichloromethane ethylacetate	HCID 21226138	—
生成物	9-(4-Methoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile	HCID 71277762	20%

反応手順

Prepared from VII and 4-methoxyaniline. Flash chromatography eluent (DCM-EtOAc, 8:2). Yield: 20%; orange solid, mp>260° C.; IR (KBr) νmax/cm−1 3346, 2977, 2361, 2227, 1644, 1609, 1581, 1503, 1460, 1377, 1354, 1303, 1239, 1164, 1129, 1051, 1032, 975, 829; 1H NMR (300 MHz, DMSO-d6) δ 8.44 (s, 1H), 7.95 (d, 1H, J=9.0 Hz), 7.70 (d, 1H, J=9.0 Hz), 7.45 (d, 2H, J=9.0 Hz), 6.99 (d, 2H, J=9.0 Hz), 3.76 (s, 3H); HRMS calcd for C17H12N5OS (M+H+): 334.0763, found 334.0758.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09446044B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-c9828695b9fc4aa999a3e2662af7e9c2
出典メモ	uspto-grants-2016_09