Ethyl 3-phenylpropionate → 2-Oxo-4-phenylbutyric acid

HRID 621174

反応式

HRID 621174 の反応式
[C:1]1([CH2:7][CH2:8][C:9]([O:11]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)[C:15]([O-:17])=[O:16].[O-]CC.[Na+]>C(O)C>[O:11]=[C:9]([CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:15]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 16237Ethyl 3-phenylpropionateHCID 2723922Sodium ethoxideHCID 21943339Ethanedioic acid, monoethyl ester

生成物 1

HCID 697322-Oxo-4-phenylbutyric acid収率 90.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 143 g of ethyl 3-phenylpropionate, 234 g of ethyl oxalate and 154 ml of 28% sodium ethoxide solution in ethanol is heated on a water bath at a bath temperature of 60°-70° C. for 1.5 hours, while distilling off the ethanol under reduced pressure. To the resulting red syrupy residue is added 1.3 liters of 15 v/v % sulfuric acid. The mixture is boiled under reflux with stirring for 15 hours, and the oil layer is separated, neutralized with 10% sodium hydroxide and extracted with ethyl acetate. The aqueous layer is made acidic with diluted sulfuric acid. The resulting oil is extracted with ethyl acetate, washed with water and dried. Removal of the ethyl acetate by distillation under reduced pressure gives 130 g of 2-oxo-4-phenylbutyric acid as an oil.

後処理

  1. temperatureis heated on a water bath at a bath temperature of 60°-70° C. for 1.5 hours
  2. distillationwhile distilling off the ethanol under reduced pressure
  3. additionTo the resulting red syrupy residue is added 1.3 liters of 15 v/v % sulfuric acid
  4. temperatureunder reflux
  5. customthe oil layer is separated
  6. extractionextracted with ethyl acetate
  7. extractionThe resulting oil is extracted with ethyl acetate
  8. washwashed with water
  9. customdried
  10. customRemoval of the ethyl acetate
  11. distillationby distillation under reduced pressure

出典と根拠

ORDレコード
ord-4c287e50f7794ffc9fd27d579d7ed34c
出典データセット
uspto-grants-1989_04
特許番号
US04822818

関連ノート

読み込み中…