Water → HCID 53840232、化合物

HRID 6212ノート

反応式

HRID 6212 の反応式
[Br-].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:12]=1.[Li]CCCC.[OH:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][N:49]1[C:58]2[C:53](=[CH:54][C:55]([CH:59]=[CH:60][CH:61]=O)=[CH:56][CH:57]=2)[CH2:52][CH2:51][CH2:50]1.O>C1(C)C=CC=CC=1>[OH:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][N:49]1[C:58]2[C:53](=[CH:54][C:55]([CH:59]=[CH:60][CH:61]=[CH:17][C:14]3[CH:13]=[CH:12][C:11]([C:3]4[O:2][C:6]5[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=5[N:4]=4)=[CH:16][CH:15]=3)=[CH:56][CH:57]=2)[CH2:52][CH2:51][CH2:50]1

参加物

6

反応物 4

HCID 962WaterHCID 54151230HCID 54151230、化合物HCID 867444264-(Benzoxazol-2-yl)tolyltriphenylphosphonium bromideHCID 178418339Butyllithium

生成物 1

HCID 53840232HCID 53840232、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a stirred mixture of 110 g (0.2 mole) of 4-(benzoxazol-2-yl)tolyltriphenylphosphonium bromide in toluene is added dropwise 0.2 mole of n-BuLi at room temperature. After 2 hours a solution of 28.7 g (0.1 mole) of 3-(N-hydroxyhexyl-1,2,3,4-tetrahydroquinolin-6-yl)acrolein in toluene is added dropwise to the mixture, and the reaction is stirred for 18 hours at room temperature. Water is added, and the solids are isolated by vacuum filtration, washed with 60% ethanol/water, and dried under vacuum. The product is purified by recrystallization from benzene.

後処理

  1. customthe solids are isolated by vacuum filtration
  2. washwashed with 60% ethanol/water
  3. customdried under vacuum
  4. customThe product is purified by recrystallization from benzene

出典と根拠

ORDレコード
ord-56e0c8bc731e4aa9a568d920148f452a
出典データセット
uspto-grants-1993_09
特許番号
US05247042

反応ノート

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