化工社化工社 化学情報印刷レポート · 研究参考用
Benzenamine, 3-ethynyl- → 9-(3-Ethynylphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 反応物 | Potassium Bromide | HCID 253877 | — |
| 反応物 | HCID 178484237 | HCID 178484237 | — |
| 溶媒 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 生成物 | 9-(3-Ethynylphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 89419678 | 84% |
反応手順
Prepared from VII and 3-ethynylaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 84%; yellow solid; mp 182° C.; IR (KBr) νmax/cm−1 3295, 3062, 2846, 2225, 1642, 1612, 1581, 1566, 1458, 1404, 1376, 1348, 1306, 1263, 1229, 1165, 1148, 1126, 971, 910, 888, 835; 1H NMR (300 MHz, DMSO-d6) δ 8.53 (d, 1H, J=8.7 Hz), 8.20 (s, 1H), 7.78 (d, 1H, J=8.7 Hz), 7.40-7.35 (m, 2H), 7.29 (m, 1H), 7.20 (m, 1H), 4.17 (s, 1H); HRMS calcd for C18H10N5S (M+H+): 328.0657, found 328.0659.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09446044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-1c85c4c9c6eb4b9fa763fe27794d7813 |
| 出典メモ | uspto-grants-2016_09 |