2,4-Dichloroaniline → 9-((2,4-Dichlorophenyl)amino)thiazolo[5,4-f]quinazoline-2-carbonitrile

関与物質

役割	名称	HCID	仕込み量
反応物	2,4-Dichloroaniline	HCID 11123	—
反応物	Potassium Bromide	HCID 253877	—
反応物	HCID 178484237	HCID 178484237	—
溶媒	Dichloromethane ethylacetate	HCID 21226138	—
生成物	9-((2,4-Dichlorophenyl)amino)thiazolo[5,4-f]quinazoline-2-carbonitrile	HCID 71277737	32%

反応手順

Prepared from VII and 2,4-dichloroaniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 32%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 3063, 2231, 1736, 1644, 1611, 1577, 1459, 1380, 1355, 1310, 1242, 1173, 1098, 1051, 983, 830, 818; 1H NMR (300 MHz, DMSO-d6) δ 8.56 (d, 1H, J=9.0 Hz), 8.21 (s, 1H), 7.80 (d, 1H, J=9.0 Hz), 7.63 (s, 1H), 7.39 (d, 1H, J=8.1 Hz), 7.25 (d, 1H, J=8.1 Hz); HRMS calcd for C16H8N5SCl2 (M+H+): 371.9877, found 371.9877.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09446044B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-44c1ad1d4dda4995a046ab5c700c2e72
出典メモ	uspto-grants-2016_09