Benzenamine, 4-methoxy-3-nitro- → 9-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

関与物質

役割	名称	HCID	仕込み量
反応物	Benzenamine, 4-methoxy-3-nitro-	HCID 123071	—
反応物	Potassium Bromide	HCID 253877	—
反応物	HCID 178484237	HCID 178484237	—
溶媒	Dichloromethane ethylacetate	HCID 21226138	—
生成物	9-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile	HCID 71277770	61%

反応手順

Prepared from VII and 3-nitro-4-methoxyaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 61%; yellow solid; mp 200-260° C.; IR (KBr) νmax/cm−1 2226, 1644, 1523, 1459, 1346, 1267, 1191, 1155, 1075, 1015, 970, 928, 890, 822; 1H NMR (300 MHz, DMSO-d6) δ 8.47 (d, 1H, J=9.0 Hz), 8.26 (s, 1H), 7.97 (d, 1H, J=9.0 Hz), 7.70 (s, 2H), 7.32 (d, 1H, J=9.0 Hz), 3.93 (s, 3H); HRMS calcd for C17H11N6O3S (M+H+): 379.0613, found 379.0614.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09446044B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-623bf30e41ce4fd68b08f0d16d40103d
出典メモ	uspto-grants-2016_09