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N,N-dimethyl-p-phenylenediamine → 9-(4-(Dimethylamino)phenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-dimethyl-p-phenylenediamine | HCID 7472 | — |
| 反応物 | Potassium Bromide | HCID 253877 | — |
| 反応物 | HCID 178484237 | HCID 178484237 | — |
| 溶媒 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 生成物 | 9-(4-(Dimethylamino)phenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277789 | 25% |
反応手順
Prepared from VII and N,N-dimethyl-p-phenylene-diamine. Flash chromatography eluent (DCM-EtOAc, 8:2). Yield: 25%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 3293, 2228, 1609, 1572, 1523, 1460, 1368, 1274, 1229, 1204, 1188, 1163, 1141, 1058, 1009, 948, 842, 811; 1H NMR (300 MHz, DMSO-d6) δ 8.52 (d, 1H, J=9.0 Hz), 8.16 (s, 1H), 7.86 (d, 1H, J=9.0 Hz), 7.37 (d, 2H, J=8.7 Hz), 6.92 (d, 2H, J=8.7 Hz), 3.00 (s, 6H); HRMS calcd for C18H15N6S (M+H+): 347.1079, found 347.1066.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09446044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-ecfffae7e1b44ba083f69cc061772332 |
| 出典メモ | uspto-grants-2016_09 |