Hydrochloric Acid → 7-methanesulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

反応式

C1C2C=CC=CC=2CCNC1.C(N1CCC2C=CC(S([Cl:29])(=O)=O)=CC=2CC1)(=O)C.C([N:33]1[CH2:39][CH2:38][C:37]2[CH:40]=[CH:41][C:42]([S:44]([CH3:47])(=[O:46])=[O:45])=[CH:43][C:36]=2[CH2:35][CH2:34]1)(=O)C.Cl>>[ClH:29].[CH3:47][S:44]([C:42]1[CH:41]=[CH:40][C:37]2[CH2:38][CH2:39][NH:33][CH2:34][CH2:35][C:36]=2[CH:43]=1)(=[O:46])=[O:45]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 14002432,3,4,5-Tetrahydro-1H-benzo(d)azepine

HCID 112656343-Acetyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

HCID 113467373-acetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonyl chloride

生成物 1

HCID 212428797-methanesulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

実験手順

Following the procedure of Examples 1 and 4, 2,3,4,5-tetrahydro-1H-3-benzazepine was converted to 3-acetyl-7-chlorosulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine and then to 3-acetyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine which was hydrolyzed with hydrochloric acid to give 7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, m.p. 275°-277° C.