Water → 6-Chloro-5-hydroxy-3,4-dihydrocarbostyril
反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2.[Cl:13]Cl.O>C(O)(=O)C>[Cl:13][C:11]1[C:2]([OH:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:12])[CH2:5][CH2:4]2参加物
5
実験手順
16.4 grams of 5-hydroxy-3,4-dihydrocarbostyril are dissolved in 300 ml of acetic acid. This solution is stirred at room temperature, and 50 ml of acetic acid solution containing 7 g of chlorine are added dropwise and the reaction is continued for 3 hours with stirring. The reaction mixture is poured into 500 ml of water and allowed to stand for 1 hour and the precipitate thus formed is separated by filtration, washed with water and then dried. Recrystallization from ethanol-water obtains 13.5 g of 6-chloro-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 209°-210° C.
後処理
- additionare added dropwise
- stirringwith stirring
- waitto stand for 1 hour
- customthe precipitate thus formed
- customis separated by filtration
- washwashed with water
- customdried
- customRecrystallization from ethanol-water
出典と根拠
- ORDレコード
- ord-dc1dd8cf247140d38e9cce63372c1a6f
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04824840
反応ノート
読み込み中…