Glycinamide → N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide

反応式

[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([O:10]CC)=O)[C:4](=[O:13])[CH2:3]1.[NH2:14][CH2:15][C:16]([NH2:18])=[O:17]>>[OH:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]([NH:14][CH2:15][C:16]([NH2:18])=[O:17])=[O:10])[C:4](=[O:13])[CH2:3]1

参加物

反応物 2

HCID 69020Glycinamide

HCID 12365604Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate

生成物 1

HCID 11701304N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide収率 43.5%

反応条件

温度: 80 °C

実験手順

A mixture of ethyl 4-hydroxy-2-oxo-1-pyrrolidineacetate (0.5 g) and glycinamide (0.6 g) was stirred under nitrogen at 80° C. for 4 hours. After cooling, the mixture was chromatographed on a silica gel column, by eluting with dichloromethane/methanol 7:3, affording the title compound (250 mg).

後処理

temperatureAfter cooling
customthe mixture was chromatographed on a silica gel column
washby eluting with dichloromethane/methanol 7:3

出典と根拠

ORDレコード: ord-76fda67fcc57443f940989b112aa1e45
出典データセット: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04824861

反応ノート

読み込み中…

参加物